This week in Journal Club at the Mathieson Lab we discussed the recently published paper by Wang et. al (2020) on the theoretical aspects of the transferability of polygenic risk scores across ancestries.
How “The Lion King” turned me into a scientistRecently, my therapist asked me to do some homework. She asked me to reflect on the question “what did I want to be when I grew up?” looking as far back into the past as I could remember. A few…
Tl; dr, I love to tell a good story. If you don’t wanna read that, no worries. Just skip ahead or get straight to business! Now, to the story. I have been working on a project where I was using population allelic frequencies for about 6,000 SNPs (single nucleotide polymorphisms) for CEU (North Americans from UTAH with European ancestry) individuals from the 1000 Genomes Project. We have our own copy of this dataset in our computer, and it’s relatively straightforward to get those frequencies from vcf files.
Summarizing the new LDpred2 method