Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
This week in Journal Club at the Mathieson Lab we discussed the recently published paper by Wang et. al (2020) on the theoretical aspects of the transferability of polygenic risk scores across ancestries.
Polygenic Risk Scores performance in diverse ancestry populations
Investigations on different methods for PRS calculation, the effects of different modelling and pruning approaches, and transferability of PRS across ancestries
LDpred2: Better, Faster, Stronger
Summarizing the new LDpred2 method